Significance of CD30 Expression by Epidermotropic T Cells in Lymphomatoid Papulosis and Lymphomatoid Pityriasis Lichenoides
نویسندگان
چکیده
Eric C Vonderheid1*, Marshall E Kadin2, Gladys H Telang3 1Adjunct Professor, Sidney Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, USA 2Professor, Department of Dermatology, Boston University and Roger Williams Medical Center, Providence, RI, USA 3Associate Professor, Department of Dermatology, The Warren Alpert Medical School of Brown University, RI, USA Clinical Research in Dermatology: Open Access Open Access Research Article
منابع مشابه
Lymphomatoid papulosis misdiagnosed as pityriasis lichenoides et varioliformis acuta: Two case reports and a literature review
The aim of this study was to improve the level of diagnosis and differential diagnosis of lymphomatoid papulosis (LyP). Two cases of type B LyP were identified and the literature was reviewed to summarize the clinical outcomes and pathology of LyP and its treatment. The two patients exhibited symptoms with papulonodular lesions, the centers of which gradually underwent ulceration and necrosis. ...
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BACKGROUND Lymphomatoid papulosis is a rare lymphoproliferative T cell CD30+ disease with excellent prognosis which affects almost exclusively adult patients, being rarely in the childhood; thus the clinic and pathologic spectrum and the risk of evolution to another type of lymphoma are not well defined in the pediatric group. OBJECTIVE The aim of this article is to analyze the characteristic...
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The t(2;5) (p23;q35) chromosomal translocation has been found in a high proportion of lymph node-based CD30+ large cell lymphomas of T-cell lineage. This translocation is believed to result in the expression of a fusion protein containing the catalytic domain of anaplastic lymphoma kinase (ALK) under the control of the promoter for nucleophosmin, a nucleolar phosphoprotein. Expression of ALK ac...
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BACKGROUND Clusterin is a ubiquitous 80 kDa heterodimeric glycoprotein previously shown to be expressed on tumor cells of systemic and, to a lesser extent, primary cutaneous anaplastic large cell lymphoma (PC-ALCL). Lymphomatoid papulosis (LyP), an important differential diagnosis of ALCL, has been studied for clusterin expression in only a small number of cases. The aim of this study was to co...
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© 2014 The Authors. doi: 10.2340/00015555-1806 Journal Compilation © 2014 Acta Dermato-Venereologica. ISSN 0001-5555 Lymphomatoid papulosis (LyP) is characterised by a chronic course of years to decades of recurrent papulonodular lesions, each of which undergoes spontaneous regression after weeks or months (1). Recently LyP type D was identified as a new histolopathological variant simulating a...
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